In his keynote lecture, Alan Liu uses the example of the formalized “interpretation protocol” for topic models he is developing for the Mellon Foundation funded WhatEvery1Says project (which is text-analyzing millions of newspaper articles mentioning the humanities) to reflect on how humanistic traditions of interpretation can contribute to machine learning. But he also suggests how machine learning changes humanistic interpretation through fresh ideas about wholes and parts, mimetic representation and probabilistic modeling, and similarity and difference (or identity and culture).